Untargeted metabolomics for profiling oncogene-specific metabolic signatures of prostate cancer
نویسندگان
چکیده
Oncogene-associated metabolic signatures in prostate cancer, identified by an integrative analysis of cultured cells and murine and human tumors, suggest that AKT activation results in a glycolytic phenotype whereas MYC induces aberrant lipid metabolism. Heterogeneity in human tumors makes this simplistic interpretation obtained from experimental models more challenging. Metabolic reprogramming as a function of distinct molecular aberrations has major diagnostic and therapeutic implications.
منابع مشابه
AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer.
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